# The Schizophrenia Drug That Nobody Expected: How a Forgotten Enzyme Could Crack the Disease’s Most Stubborn Problem

- URL: https://theranews.net/blog/2026-03-21-the-schizophrenia-drug-that-nobody-expected-how-a-forgotten-enzyme-could-crack-t-054c55/
- Published: 2026-03-21
- Type: Archive summary (AI-assisted summary of third-party reporting)
- Original outlet: webpronews
- Original report: https://www.webpronews.com/the-schizophrenia-drug-that-nobody-expected-how-a-forgotten-enzyme-could-crack-the-diseases-most-stubborn-problem/
- Topics: mental-health
- Publisher: TheraNews, operated by AdvancedCare USA Inc.
- Notice: Educational content, not medical, legal, billing or financial advice. Cite the original outlet, not this summary.

> Northwestern researchers have identified HDAC5, an overexpressed brain enzyme, as a biomarker and drug target for schizophrenia's untreatable cognitive symptoms. Their selective inhibitor restored cognition in animal models, offering the first credible therapeutic approach to the disease's most disa

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![The Schizophrenia Drug That Nobody Expected: How a Forgotten Enzyme Could Crack the Disease’s Most Stubborn Problem](/uploads/news-images/the-schizophrenia-drug-that-nobody-expected-how-a-20260321110054.jpeg)

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*Originally reported by webpronews. [Read more](https://www.webpronews.com/the-schizophrenia-drug-that-nobody-expected-how-a-forgotten-enzyme-could-crack-the-diseases-most-stubborn-problem/)*

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*Source: [https://www.webpronews.com/the-schizophrenia-drug-that-nobody-expected-how-a-forgotten-enzyme-could-crack-the-diseases-most-stubborn-problem/](https://www.webpronews.com/the-schizophrenia-drug-that-nobody-expected-how-a-forgotten-enzyme-could-crack-the-diseases-most-stubborn-problem/)*